Somatic gene mutations and their association with treatment outcomes among Indo-Asian Lung Cancer patients

This retrospective study highlights the molecular heterogeneity among lung cancer patients with EGFR and P53 being most frequent. While targeted therapies improved outcomes in mutation-positive patients, KRAS mutations correlated with resistance. Broader access to molecular testing and targeted treatments is essential for optimizing care in resource-limited settings.

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Publication Details

Journal
Cancer Treatment and Research Communications
Published
2025-11-20
DOI
https://doi.org/10.1016/j.ctarc.2025.101039
Primary Topic
Lung Cancer Treatments and Mutations
Type
article
Field-Weighted Citation Impact
0.00
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article

Somatic gene mutations and their association with treatment outcomes among Indo-Asian Lung Cancer patients

Pradeep Narayan, Anuja Pradhan, Safeena Kulsum, Shaesta Naseem Zaidi et al.
Cancer Treatment and Research Communications
Lung Cancer Treatments and Mutations
article

Somatic gene mutations and their association with treatment outcomes among Indo-Asian Lung Cancer patients

Pradeep Narayan, Anuja Pradhan, Safeena Kulsum, Shaesta Naseem Zaidi, Pragnya Coca
article en

Abstract

This retrospective study highlights the molecular heterogeneity among lung cancer patients with EGFR and P53 being most frequent. While targeted therapies improved outcomes in mutation-positive patients, KRAS mutations correlated with resistance. Broader access to molecular testing and targeted treatments is essential for optimizing care in resource-limited settings.

Cancer Treatment and Research CommunicationsVol. 46
Narayana Health (IN)
Openalex Percentile: Top 49%
Lung Cancer Treatments and Mutations
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