Exploring the interaction between klotho and TyG index in cardiovascular risk stratification: A metabolic-inflammatory network analysis with mediation and machine learning insights
This study underscores the TyG index as a key biomarker for CVD risk, with the Klotho-TyG interaction improving risk stratification, and supporting early screening, treatment, and personalized interventions for more effective CVD management.
Authors
- Jieqing Min
- Yunjuan Yang (ORCID: https://orcid.org/0000-0002-3580-4434)
Institutions
- Kunming Medical University (CN)
- Kunming Children's Hospital (CN)
- Yunnan Center for Disease Control And Prevention (CN)
- Dali University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- American Heart Journal Plus Cardiology Research and Practice
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.ahjo.2025.100681
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00