Feasibility to infer accurate fibrinogen concentrations from thrombin generation, prothrombin time, or Reptilase time waveforms
Our mathematical methods proved to be able to accurately infer a wide range of fibrinogen levels in real-world patient samples, even in the presence of anticoagulant medication. With this study, we took the first step toward the development of a new, rapid point-of-care fibrinogen test.
Authors
- Jeroen C.J. Eikenboom (ORCID: https://orcid.org/0000-0002-3268-5759)
- René van den Ham
- Ryanne A. Arisz (ORCID: https://orcid.org/0000-0003-2113-9530)
- Moniek P.M. de Maat (ORCID: https://orcid.org/0000-0001-7749-334X)
- Saskia E.M. Schols (ORCID: https://orcid.org/0000-0003-2423-2829)
- Aamer Ahmed
- Bart Bakker
Institutions
- Radboud University Nijmegen (NL)
- Leiden University Medical Center (NL)
- Erasmus MC (NL)
- Radboud University Medical Center (NL)
- Gemeente Amsterdam (NL)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-11-01
- DOI
- https://doi.org/10.1016/j.rpth.2025.103269
- Primary Topic
- Blood properties and coagulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek