Vancomycin-specific Urinary Immunostaining for Noninvasive Screening of Vancomycin-associated Cast Nephropathy
<h2>Abstract</h2> Vancomycin is a widely used antibiotic and a known cause of acute kidney injury (V-AKI). Recent studies suggest that vancomycin can form obstructive aggregates with uromodulin in kidney tubules, contributing to acute kidney injury (V-AKI). However, detecting these aggregates typically requires kidney tissue for immunostaining. Urine-based vancomycin immunostaining has been proposed as a non-invasive alternative for diagnosing V-AKI, but its specificity remains uncertain.
Authors
- Rémi Chieze
- Cédric Rafat (ORCID: https://orcid.org/0000-0002-1093-0514)
- Lara Zafrani
- Yosu Luque (ORCID: https://orcid.org/0000-0002-3172-6571)
- David Rozenblat (ORCID: https://orcid.org/0009-0006-7771-0053)
- Emmanuel Letavernier (ORCID: https://orcid.org/0000-0002-6053-8975)
- Ellie Tang (ORCID: https://orcid.org/0000-0003-4004-5812)
- Stéphane Gaudry (ORCID: https://orcid.org/0000-0002-1105-6785)
- Jeremy Zavorski
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Université Sorbonne Paris Nord (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Avicenne (FR)
- Centre de Recherche Saint-Antoine (FR)
- Hôpital Saint-Louis (FR)
- Hôpital Tenon (FR)
- Maladies rénales fréquentes et rares : des mécanismes moléculaires à la médecine personnalisée
Publication Details
- Journal
- Kidney Medicine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.xkme.2025.101188
- Primary Topic
- Acute Kidney Injury Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00