Stress History Modulates Corticotropin-Releasing Factor Neurons to Establish Resilience
Our study reveals a novel process by which individuals may persist in the face of adversity by way of stress-provoked activation, not inhibition of a key CRF limbic region that establishes a pathway to resilience.
Authors
- Carole Morel (ORCID: https://orcid.org/0000-0002-5076-1938)
- Sherod E. Haynes (ORCID: https://orcid.org/0000-0002-0170-681X)
- Helen S. Mayberg (ORCID: https://orcid.org/0000-0002-1672-2716)
- Anthony F. Lacagnina (ORCID: https://orcid.org/0000-0003-1722-1611)
- Donald G. Rainnie (ORCID: https://orcid.org/0000-0003-0758-0530)
- Ming‐Hu Han (ORCID: https://orcid.org/0000-0001-8613-4824)
- Muhammad Furqan Afzal (ORCID: https://orcid.org/0000-0002-8476-4539)
- Aurélie Menigoz
- Kanaka Rajan (ORCID: https://orcid.org/0000-0003-2749-2917)
- Roger L. Clem (ORCID: https://orcid.org/0000-0002-8965-9455)
- Barbara Juarez
- Larry J. Young (ORCID: https://orcid.org/0000-0003-2044-2239)
- Xiao Yang (ORCID: https://orcid.org/0000-0003-1504-4949)
- Li Fang (ORCID: https://orcid.org/0009-0008-6436-8388)
- H.S. Seo
Institutions
- Oregon National Primate Research Center (US)
- University of Maryland, Baltimore (US)
- Allen Institute for Brain Science (US)
- Emory University (US)
- Chinese Academy of Sciences (CN)
- Circuit Therapeutics (United States) (US)
- Shenzhen University Health Science Center (CN)
- Shenzhen Institutes of Advanced Technology (CN)
- Artificial Intelligence in Medicine (Canada) (CA)
- Stanford University (US)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100656
- Citations
- 1
- Primary Topic
- Stress Responses and Cortisol
- Type
- article
- Field-Weighted Citation Impact
- 1.11