Spatial Multiomic Analyses Reveal Carcinogenic Pathways in End-Stage Renal Disease
We elucidated the molecular basis of renal cancer arising in patients with ESRD and show that the inflammatory environment of ESRD gives rise to field cancerization. See related commentary by Sager et al., p. 426.
Authors
- Ibuki Tsuru (ORCID: https://orcid.org/0000-0002-7309-3362)
- Tetsuo Ushiku (ORCID: https://orcid.org/0000-0002-1763-8380)
- Genki Okumura (ORCID: https://orcid.org/0009-0007-3385-8889)
- Hiroyoshi Nishikawa (ORCID: https://orcid.org/0000-0001-6563-9807)
- Akihiko Fukagawa (ORCID: https://orcid.org/0009-0009-0712-7542)
- Yusuke Sato (ORCID: https://orcid.org/0000-0002-6239-6050)
- Shohei Koyama (ORCID: https://orcid.org/0000-0002-6897-9417)
- Yuta Yamada (ORCID: https://orcid.org/0000-0002-9698-4301)
- Haruki Kume (ORCID: https://orcid.org/0000-0001-9841-0857)
- Toshihide Ueno (ORCID: https://orcid.org/0000-0002-7408-7298)
- Yasuhiro Kojima (ORCID: https://orcid.org/0000-0002-1363-7153)
- Shinya Kojima (ORCID: https://orcid.org/0009-0002-3223-2634)
- Hiroyuki Mano (ORCID: https://orcid.org/0000-0003-4645-0181)
- Yosuke Tanaka (ORCID: https://orcid.org/0000-0002-3764-0517)
- Sayuri Takahashi (ORCID: https://orcid.org/0000-0002-6991-026X)
- Hisashi Hashimoto (ORCID: https://orcid.org/0000-0001-9495-3811)
- Jun Takahashi (ORCID: https://orcid.org/0009-0000-4955-7414)
- Ryohei Kuroda (ORCID: https://orcid.org/0000-0002-2419-7501)
- Atsushi Kondo (ORCID: https://orcid.org/0009-0008-4105-4730)
Institutions
- Tokyo Medical University (JP)
- National Cancer Centre Japan (JP)
- University of Tokyo Hospital (JP)
- Tokyo Metropolitan Tama Medical Center (JP)
- National Cancer Research Institute (GB)
- The University of Tokyo (JP)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0472
- Primary Topic
- Renal cell carcinoma treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00