MetALD Was an Independent Risk Factor for the Recurrence of Early Esophageal Squamous Cell Carcinoma After Endoscopic Resection: A Multicenter Cohort Study Using Directed Acyclic Graphs
MetALD is an independent risk factor for ESCC recurrence after curative ESD, especially among non-abstainers. These findings suggest the synergistic oncogenic potential of moderate alcohol intake and MASLD, and underscore the importance of lifestyle and metabolic interventions in post-ESD management.
Authors
- Takuji Torimura (ORCID: https://orcid.org/0000-0002-4863-4278)
- Dan Nakano (ORCID: https://orcid.org/0000-0001-6098-1224)
- Taku Morita (ORCID: https://orcid.org/0009-0007-1683-9109)
- Tsubasa Tsutsumi (ORCID: https://orcid.org/0000-0001-6571-9874)
- Keigo Emori
- Tomonori Cho (ORCID: https://orcid.org/0000-0002-4861-8809)
- Yutaka Watanabe (ORCID: https://orcid.org/0000-0002-4983-2399)
- Tomoyuki Nakane
- Ryuichi Nouno
- Shuhei Fukunaga (ORCID: https://orcid.org/0000-0002-2715-7564)
- Hidetoshi Takedatsu (ORCID: https://orcid.org/0000-0002-0318-0129)
- Michita Mukasa
- Yoshio Terada
- Hiroshi Tanaka (ORCID: https://orcid.org/0000-0002-8003-7326)
- Takumi Kawaguchi (ORCID: https://orcid.org/0000-0002-7064-4325)
- Toshihiro Araki
- Shinpei Minami
- Daiki Ohzono
Institutions
- Kurume University (JP)
- Kurume University Medical Center (JP)
- Omuta hospital (JP)
- Kumamoto Chuo Hospital (JP)
Publication Details
- Journal
- Hepatology Research
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1111/hepr.70080
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00