Application of functional magnetic resonance imaging in identifying responsible brain regions associated with spinal diseases related pain
Resting-state brain fMRI indicates a cerebello-thalamo-cortical alteration pattern in spinal diseases related pain featuring cerebellar involvement, prefrontal subspecialization, and multilevel sensorimotor disruption. These cross-sectional associations may inform hypothesis-generation for future neuromodulation studies and provide candidate biomarkers for monitoring, pending prospective validation.
Authors
- Yuehuan Zheng (ORCID: https://orcid.org/0000-0003-1962-3673)
- Lemeng Ren (ORCID: https://orcid.org/0009-0000-4955-4002)
- Junpeng Zhang (ORCID: https://orcid.org/0000-0001-6127-9701)
- Jing Zhang
- Xiaopei Sun
- Nannan Wang
Institutions
- Shanghai Jiao Tong University (CN)
- Ruijin Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fmed.2025.1585799
- Primary Topic
- Pain Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00