Periostin Promotes Sarcoma Growth by Promoting Tumor-Associated Macrophage Migration and Differentiation
Our findings position POSTN as a key stromal regulator in STS, linking tumor-derived ECM components to immune evasion via myeloid cell recruitment and education. These results open avenues for targeting POSTN as an adjuvant strategy to enhance the efficacy of immunotherapies and overcome the immune-excluded phenotype of sarcoma.
Authors
- Jlenia Guarnerio (ORCID: https://orcid.org/0000-0001-7576-7095)
- Kristin Ishaya (ORCID: https://orcid.org/0009-0008-5750-9824)
- Marina T. Broz (ORCID: https://orcid.org/0000-0003-2875-9273)
- Emily Ko (ORCID: https://orcid.org/0000-0002-4893-3227)
- Jin-Fen Xiao (ORCID: https://orcid.org/0000-0003-3366-5984)
- Annaliese Fowler (ORCID: https://orcid.org/0009-0002-8510-2219)
Institutions
- Cedars-Sinai Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- National University of Singapore (SG)
- University of California System (US)
- Los Angeles Medical Center (US)
Publication Details
- Journal
- Cancer Research Communications
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1158/2767-9764.crc-25-0301
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Cedars-Sinai Medical Center
- National Cancer Institute