Air pollution exacerbates cardiovascular-kidney-metabolic syndrome and sarcopenia comorbidity via shared genetic-epigenetic mechanisms: A multi-omics and Mendelian Randomization study
Ambient air pollution likely promotes CKM-sarcopenia comorbidity chiefly via inflammatory signaling and epigenetic modifications. Our multi-omics integration reveals convergent pathways, candidate driver genes, and differential methylation sites that link these conditions. We propose these targets for environmental mitigation and molecular intervention, which require validation in diverse populations.
Authors
- Lingbin He
- Ronghuai Shen
- Xianxi Huang (ORCID: https://orcid.org/0000-0001-5978-5031)
- Ling Xiao
- Xinyi Li (ORCID: https://orcid.org/0000-0002-8415-0385)
- Yu Zhang (ORCID: https://orcid.org/0000-0001-9211-861X)
- Zhouwu Shu
- Shuxu Wei
- Xiaojia Lu
- Suiqin Zhong (ORCID: https://orcid.org/0009-0007-1521-3569)
- Yan Quan (ORCID: https://orcid.org/0009-0000-6056-1414)
Institutions
- Shantou University (CN)
- First Affiliated Hospital of Shantou University Medical College (CN)
- Jiangxi Institute Of Economic Administraors (CN)
Publication Details
- Journal
- Metabolism
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.metabol.2025.156452
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00