Creatine kinase imaging (CKI) for in vivo whole-brain mapping of creatine kinase reaction kinetics

The creatine kinase (CK) is a key enzyme involved in brain bioenergetics, playing an important role in brain function and the pathogenesis of neurological and psychiatric diseases and cancers. However, imaging its activity noninvasively in the human brain remains a significant challenge. This study aims to advance <sup>31</sup>P magnetic resonance fingerprinting for Creatine Kinase Imaging (CKI). The method was implemented and validated on a clinical 7 Tesla MRI scanner. CKI enables whole-brain mapping of CK forward rate constant, revealing regional differences. Furthermore, a functional CKI (fCKI) study demonstrated a CK activation map in response to visual stimulation, revealing an increase in CK forward rate constant in the visual cortex. The novel imaging modalities, CKI and fCKI, have the potential to offer insights into brain bioenergetics both at rest and during activity, in both healthy and pathological conditions.

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Publication Details

Journal
Proceedings of the National Academy of Sciences
Published
2025-11-20
DOI
https://doi.org/10.1073/pnas.2505323122
Citations
1
Primary Topic
Advanced MRI Techniques and Applications
Type
article
Field-Weighted Citation Impact
1.36
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Creatine kinase imaging (CKI) for in vivo whole-brain mapping of creatine kinase reaction kinetics

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Advanced MRI Techniques and Applications
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Creatine kinase imaging (CKI) for in vivo whole-brain mapping of creatine kinase reaction kinetics

Zhiwei Huang, Mark Widmaier, Daniel Wenz, Song‐I Lim, Ying Xiao, Antonia Kaiser, Lijing Xin, André Döring, Yan Lin, Yun Jiang, Pontus Pandurevic
article en
1 citations

Abstract

The creatine kinase (CK) is a key enzyme involved in brain bioenergetics, playing an important role in brain function and the pathogenesis of neurological and psychiatric diseases and cancers. However, imaging its activity noninvasively in the human brain remains a significant challenge. This study aims to advance <sup>31</sup>P magnetic resonance fingerprinting for Creatine Kinase Imaging (CKI). The method was implemented and validated on a clinical 7 Tesla MRI scanner. CKI enables whole-brain mapping of CK forward rate constant, revealing regional differences. Furthermore, a functional CKI (fCKI) study demonstrated a CK activation map in response to visual stimulation, revealing an increase in CK forward rate constant in the visual cortex. The novel imaging modalities, CKI and fCKI, have the potential to offer insights into brain bioenergetics both at rest and during activity, in both healthy and pathological conditions.

Proceedings of the National Academy of SciencesVol. 122(47)
University of Michigan (US), Shantou University (CN), Metabolic Technologies (United States) (US), Michigan Medicine (US), Shantou University Medical College (CN), Second Affiliated Hospital of Shantou University Medical College (CN), Centre d'Imagerie BioMedicale (CH), École Polytechnique Fédérale de Lausanne (CH)
Openalex Percentile: Top 14%
Advanced MRI Techniques and Applications
1.36
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