Follicular Mucinosis in a Young Male: A Case Report and Literature Review

Follicular mucinosis (FM), also known as alopecia mucinosa, is an uncommon cutaneous mucinosis defined by the deposition of glycosaminoglycan-rich mucin within the pilosebaceous unit. This abnormal accumulation primarily affects the outer root sheath of hair follicles and sebaceous glands, resulting in follicular epithelial degeneration, inflammatory infiltration, and disruption of follicular architecture. Clinically, FM manifests as erythematous papules, indurated plaques, and localized areas of alopecia. We present the case of a 21-year-old male with a five-month history of a localized forehead lesion that demonstrated characteristic clinical and histopathologic features of FM, followed by a concise review of relevant literature.

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Journal
Cureus
Published
2025-11-20
DOI
https://doi.org/10.7759/cureus.97338
Primary Topic
Cutaneous lymphoproliferative disorders research
Type
article
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0.00
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article

Follicular Mucinosis in a Young Male: A Case Report and Literature Review

Humoud Al‐Sabah, Nourah Alazemi, Dana B Sakhi, Fatema Shamsaldeen
Cureus
Cutaneous lymphoproliferative disorders research
article

Follicular Mucinosis in a Young Male: A Case Report and Literature Review

Humoud Al‐Sabah, Nourah Alazemi, Dana B Sakhi, Fatema Shamsaldeen
article en

Abstract

Follicular mucinosis (FM), also known as alopecia mucinosa, is an uncommon cutaneous mucinosis defined by the deposition of glycosaminoglycan-rich mucin within the pilosebaceous unit. This abnormal accumulation primarily affects the outer root sheath of hair follicles and sebaceous glands, resulting in follicular epithelial degeneration, inflammatory infiltration, and disruption of follicular architecture. Clinically, FM manifests as erythematous papules, indurated plaques, and localized areas of alopecia. We present the case of a 21-year-old male with a five-month history of a localized forehead lesion that demonstrated characteristic clinical and histopathologic features of FM, followed by a concise review of relevant literature.

CureusVol. 17(11)
Farwaniya Hospital (KW), Kuwait Institute for Medical Specialization (KW), Al-Salam Hospital (LB), Central Dermatology (US)
Openalex Percentile: Top 42%
Cutaneous lymphoproliferative disorders research
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