Gain of visceral adipose tissue rather than low skeletal muscle mass is associated with overall survival in patients with colorectal liver metastases; results from the NewEPOC study
The body composition features SM and SM-RA decreased during chemotherapy, but were not associated with survival. On the contrary, although VAT did not significantly change, the gain of VAT was an independent prognostic factor for survival. These results should be validated in independent cohorts but may indicate that in this selected patient group, adipose tissue might be a more important prognostic factor than sarcopenia.
Authors
- John Primrose (ORCID: https://orcid.org/0000-0002-2069-7605)
- David P.J. van Dijk (ORCID: https://orcid.org/0000-0002-2019-5402)
- Malcolm West (ORCID: https://orcid.org/0000-0002-0345-5356)
- Steven W.M. Olde Damink (ORCID: https://orcid.org/0000-0002-5202-9345)
- Zina Eminton (ORCID: https://orcid.org/0009-0001-2747-4279)
- Merel R. Aberle (ORCID: https://orcid.org/0000-0003-1990-1784)
- Sander S. Rensen (ORCID: https://orcid.org/0000-0001-5054-8400)
- S. Pugh (ORCID: https://orcid.org/0000-0002-1866-8338)
- Marjolein A. P. Ligthart (ORCID: https://orcid.org/0000-0002-4675-927X)
- John A. Bridgewater (ORCID: https://orcid.org/0000-0001-9186-1604)
Institutions
- Maastricht University Medical Centre (NL)
- University Hospital Southampton NHS Foundation Trust (GB)
- Maastricht University (NL)
- London Cancer (GB)
- NIHR Southampton Biomedical Research Centre (GB)
- Addenbrooke's Hospital (GB)
- University of Southampton (GB)
- University College London (GB)
Publication Details
- Journal
- European Journal of Surgical Oncology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.ejso.2025.111179
- Primary Topic
- Nutrition and Health in Aging
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Cancer Research UK
- Universiteit Maastricht
- NUTRIM School of Nutrition and Translational Research in Metabolism