Apocrine carcinoma of the breast: distinctive metabolic reprogramming and high‐frequency <scp>PIK3CA</scp> mutations revealed by molecular and immunohistochemical analysis
AC is characterized by distinct metabolic reprogramming, with preferential upregulation of peroxisomal β-oxidation rather than mitochondrial pathways. These metabolic features are accompanied by a high prevalence of activating PIK3CA mutations, suggesting a link between genomic alterations and metabolic phenotype. These findings provide new insights into the pathobiology of AC and may assist in its histopathological differentiation from other breast cancer subtypes.
Authors
- Nobuyoshi Kittaka (ORCID: https://orcid.org/0000-0002-0906-1155)
- Kenichi Yoshida (ORCID: https://orcid.org/0000-0002-1549-1514)
- Takahiro Nakayama (ORCID: https://orcid.org/0000-0002-3713-1624)
- Hiroki Kusama (ORCID: https://orcid.org/0000-0002-2163-7989)
- Harumi Nakamura (ORCID: https://orcid.org/0000-0003-4476-8794)
- Fumio Imamura (ORCID: https://orcid.org/0009-0009-5961-2101)
- Yoji Kukita (ORCID: https://orcid.org/0000-0003-3523-2816)
- Kei Kunimasa (ORCID: https://orcid.org/0000-0002-5241-3486)
- Toshinari Yagi
- Yasuhiro Tamaki (ORCID: https://orcid.org/0000-0002-9430-2549)
Institutions
- Osaka Rosai Hospital (JP)
- Osaka International Cancer Institute (JP)
- Takarazuka City Hospital (JP)
Publication Details
- Journal
- Histopathology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1111/his.70024
- Citations
- 1
- Primary Topic
- Cancer Risks and Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.05