Exosomes derived from ovarian cancer promote the progression of ovarian cancer through macrophage M2 polarization mediated by the THBS1/TGFBI signaling axis
THBS1, carried by ovarian cancer-derived exosomes, promotes M2 polarization of TAMs by modulating TGFBI expression. The subsequent M2 polarization of TAMs contributes to the establishment of an immunosuppressive tumor microenvironment, thereby facilitating disease progression. Consequently, targeting the exosome-mediated signaling axis between cancer cells and macrophages represents a promising avenue for developing novel therapeutic interventions.
Authors
- Shaojia Wang (ORCID: https://orcid.org/0000-0001-9347-9695)
- Lingfeng Zhao (ORCID: https://orcid.org/0009-0008-5368-8829)
- Jia Yue (ORCID: https://orcid.org/0000-0003-0577-5289)
- Linlin Yang (ORCID: https://orcid.org/0000-0003-2371-2951)
- Xinyue Feng
- Shufen Tan (ORCID: https://orcid.org/0000-0002-3235-9988)
- Yan Qin (ORCID: https://orcid.org/0000-0002-6187-601X)
- Meng Xiang (ORCID: https://orcid.org/0000-0002-3052-2251)
- Hui Liu (ORCID: https://orcid.org/0000-0002-4867-7788)
- Ying Liu (ORCID: https://orcid.org/0000-0003-4168-2688)
- Hongying Yang (ORCID: https://orcid.org/0009-0004-9113-473X)
- He Zhao (ORCID: https://orcid.org/0000-0002-3988-2851)
- Chunyan Ding
- Changqing Zeng (ORCID: https://orcid.org/0000-0002-6120-1725)
- Haijuan Zhao (ORCID: https://orcid.org/0000-0002-5058-9621)
- Yu‐Ye Li (ORCID: https://orcid.org/0000-0003-0676-985X)
- Ruolan Xu (ORCID: https://orcid.org/0000-0002-6594-8930)
- Youqin Ruan
Institutions
- Kunming Medical University (CN)
Publication Details
- Journal
- Cellular Immunology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.cellimm.2025.105054
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00