Lacosamide is Associated with a Higher Treatment Persistence at 12 Months than Brivaracetam and Perampanel Despite Similar Efficacy
Treatment discontinuation in epilepsy emerges as a dynamic process shaped by both tolerability and clinical response. Early persistence was higher for LCM, whereas long-term retention was improved for BRV and PER. These results support a personalized approach to ASM selection that integrates early tolerability with sustained effectiveness.
Authors
- Angela La Neve (ORCID: https://orcid.org/0000-0001-6776-9007)
- Francesca Anzellotti (ORCID: https://orcid.org/0000-0002-5150-604X)
- Payam Tabaee Damavandi (ORCID: https://orcid.org/0000-0003-2514-2155)
- Roberta Roberti (ORCID: https://orcid.org/0000-0002-2633-7635)
- Angelo Pascarella (ORCID: https://orcid.org/0000-0002-0085-9494)
- Valeria Badioni
- Gionata Strigaro (ORCID: https://orcid.org/0000-0003-4115-3874)
- Sara Gasparini (ORCID: https://orcid.org/0000-0001-6779-435X)
- Francesco Fortunato (ORCID: https://orcid.org/0000-0001-8395-7809)
- Vincenzo Belcastro (ORCID: https://orcid.org/0000-0002-3416-2900)
- Andrea Maialetti (ORCID: https://orcid.org/0000-0002-8428-4797)
- Stefano Luca Sensi (ORCID: https://orcid.org/0000-0002-0710-2574)
- Giovanni Falcicchio (ORCID: https://orcid.org/0000-0003-0745-5246)
- Alfonso Giordano (ORCID: https://orcid.org/0000-0001-6518-0119)
- Jacopo Cosimo DiFrancesco (ORCID: https://orcid.org/0000-0002-4102-1188)
- Alberto Danieli (ORCID: https://orcid.org/0000-0002-8390-5897)
- Annacarmen Nilo (ORCID: https://orcid.org/0000-0001-9827-8059)
- Simona Lattanzi (ORCID: https://orcid.org/0000-0001-8748-0083)
- Roberta Di Giacomo (ORCID: https://orcid.org/0000-0003-4202-955X)
- Maria Grazia Pascarella
- Giacomo Evangelista (ORCID: https://orcid.org/0000-0002-1828-5345)
- Lorenzo Verriello (ORCID: https://orcid.org/0000-0002-5301-8621)
- Laura Canafoglia (ORCID: https://orcid.org/0000-0002-5385-761X)
- Mariana Fernandes (ORCID: https://orcid.org/0000-0002-7005-2805)
- Simone Beretta (ORCID: https://orcid.org/0000-0002-9417-2748)
- Carmen De Caro (ORCID: https://orcid.org/0000-0003-3549-5958)
- Pio Zoleo
- Claudia Cagnetti (ORCID: https://orcid.org/0000-0002-2431-1407)
- Miriam Olivieri
- Fedele Dono (ORCID: https://orcid.org/0000-0003-3575-2942)
- Cristina Politi (ORCID: https://orcid.org/0000-0003-1473-0330)
- Antonio Gambardella (ORCID: https://orcid.org/0000-0001-7384-3074)
- Pietro Mattioli (ORCID: https://orcid.org/0000-0003-2563-5830)
- Emilio Russo (ORCID: https://orcid.org/0000-0002-1279-8123)
- Marta Maschio (ORCID: https://orcid.org/0000-0002-3075-4108)
- Alfredo D’Aniello (ORCID: https://orcid.org/0000-0002-1169-615X)
- Francesco Deleo (ORCID: https://orcid.org/0000-0003-0808-3042)
- Gianfranco Di Gennaro (ORCID: https://orcid.org/0000-0002-7204-4091)
- Flavio Villani (ORCID: https://orcid.org/0000-0002-2762-4599)
- Lorenzo Tinti (ORCID: https://orcid.org/0000-0002-3236-5325)
- Chiara Bedetti (ORCID: https://orcid.org/0000-0001-6722-8657)
- Ugo Leggio
- Vincenzo Andreone (ORCID: https://orcid.org/0000-0002-9590-9414)
- Giada Pauletto (ORCID: https://orcid.org/0000-0002-8875-6640)
- Giovanni Boero (ORCID: https://orcid.org/0000-0003-4803-064X)
- Francesca Felicia Operto (ORCID: https://orcid.org/0000-0002-2444-8761)
- Roberto Cantello (ORCID: https://orcid.org/0000-0001-6999-5729)
- Angelo Labate (ORCID: https://orcid.org/0000-0002-8827-7324)
- Paolo Bonanni (ORCID: https://orcid.org/0000-0002-9448-9059)
- Nicola Biagio Mercuri (ORCID: https://orcid.org/0000-0001-6700-7491)
- Dario Arnaldi (ORCID: https://orcid.org/0000-0001-6823-6069)
- Elisa Osanni
- Claudio Liguori (ORCID: https://orcid.org/0000-0003-2845-1332)
- Rosaria Renna
- Matilde Lazzari (ORCID: https://orcid.org/0000-0003-2835-6511)
- Giancarlo Di Gennaro (ORCID: https://orcid.org/0000-0003-3446-0788)
- Luciano Antonio Nassar Pellegrino
- Chiara Pastori
- Filippo Dainese
- Nicoletta Foschi
- Edoardo Ferlazzo
- Lara Buttarelli
Institutions
- University of Messina (IT)
- University of Rome Tor Vergata (IT)
- Marche Polytechnic University (IT)
- Università degli Studi del Piemonte Orientale “Amedeo Avogadro” (IT)
- University of Udine (IT)
- University of Sannio (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- Istituto Neurologico Mediterraneo (IT)
- Magna Graecia University (IT)
- University of Chieti-Pescara (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Azienda Ospedaliero Universitaria Maggiore della Carita (IT)
- Ospedale Santa Maria della Misericordia di Udine (IT)
- Azienda Socio Sanitaria Territoriale Lariana (IT)
- National Cancer Institute (MY)
- Ospedale Policlinico San Martino (IT)
- Ospedale SS. Annunziata (IT)
- Ospedale Maggiore di Lodi (IT)
- IRCCS Eugenio Medea (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- National Research Council (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- University of Bari Aldo Moro (IT)
- University of Naples Federico II (IT)
- University of Genoa (IT)
Publication Details
- Journal
- Neurology and Therapy
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1007/s40120-025-00860-5
- Citations
- 1
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- Università degli Studi di Genova
- Università degli Studi G. d'Annunzio Chieti - Pescara
- Università degli Studi di Salerno
- Università degli Studi di Roma Tor Vergata
- Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze