Emulgel with Origanum vulgare L. Oil: A New Therapeutic Proposal in Case of Dermal Bacterial Infections

<b>Background</b>: The treatment of bacterial dermatological diseases is currently facing major difficulties, determined by the alarming increase in the resistance of pathogenic bacteria to conventional therapies. In this context, a viable and effective alternative is represented by the use of phytocompounds to obtain the desired therapeutic effect. The essential oil of <i>Origanum vulgare</i> L. stands out for its antibacterial, anti-aging, collagen synthesis stimulating and wound healing properties. However, its use is limited by certain disadvantages, such as poor stability and the risk of skin irritation due to accumulation in the dermis. <b>Method</b>: The process of formulating the emulgel with oregano oil respected the specific technological steps. The resulting emulgel was subjected to a series of tests, including organoleptic, stability and antimicrobial efficacy determinations. In addition, an in vivo study was conducted to confirm the lack of irritation, involving six groups of patients differentiated by age, sex and skin phenotype. <b>Results</b>: The test results revealed that the emulgel formulated with oregano oil is stable, has organoleptic properties and an appropriate pH for topical use. The product demonstrated antibacterial efficacy against <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. In addition, short-term in vivo tests (20 min-96 h) confirmed the safety and absence of skin irritation, indicating its potential as an effective alternative treatment. <b>Conclusions</b>: In conclusion, the emulgel with origanum oil represents an innovative formulation for topical application. The product is well tolerated by the skin and does not cause irritation, and its antibacterial properties validate it as a promising therapeutic solution.