Targeting neuregulin-1 in cartilage homeostasis restoration: Kaempferol-3-o-rutinoside as a novel treatment for osteoarthritis
KR was found to directly target the NRG1/AKT/mTOR axis, thereby conferring dual chondroprotective and bone-preserving effects in OA. These findings highlight the potential of KR as a therapeutic agent for OA.
Authors
- Chengai Wu (ORCID: https://orcid.org/0000-0002-6366-4758)
- Qianqian Wang (ORCID: https://orcid.org/0000-0003-2574-0120)
- Yueyang Sheng
- Jianfeng Tao
- Yongcan Wang (ORCID: https://orcid.org/0000-0002-4040-5753)
- Ying Wang (ORCID: https://orcid.org/0000-0001-6749-3848)
- Xinyu Wang (ORCID: https://orcid.org/0000-0002-3568-2211)
- Chao Wang (ORCID: https://orcid.org/0000-0001-5664-2350)
- Penglei Cui (ORCID: https://orcid.org/0000-0003-0319-9273)
- Shan Li (ORCID: https://orcid.org/0009-0005-3300-9938)
- Yanzhuo Zhang (ORCID: https://orcid.org/0000-0002-7939-7666)
- Xu Jiang (ORCID: https://orcid.org/0000-0001-5546-0192)
Institutions
- Peking University (CN)
- Beijing Jishuitan Hospital (CN)
- Beijing Ditan Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.phymed.2025.157562
- Citations
- 1
- Primary Topic
- Osteoarthritis Treatment and Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 1.67