MMP11 promotes immune escape in esophageal carcinoma cells via the PD-L1/c-Myc signaling pathway
These findings suggest that MMP11 activates the PD-L1/c-Myc pathway, contributing to immune evasion and ESCA progression. Targeting MMP11 could thus serve as a potential therapeutic approach for ESCA immunotherapy.
Authors
- Xuelei Lou
- Zukuan Chang
- Huilin Lu
- Shixing Li
- Jing Liu (ORCID: https://orcid.org/0000-0002-6805-8503)
Institutions
- Xinxiang Central Hospital (CN)
Publication Details
- Journal
- Translational Oncology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.tranon.2025.102604
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 0.00