Decoding LL-37: Structure and antimicrobial mechanisms against microbial threats
LL-37 presents a potential medicinal possibility due to its broad-spectrum antimicrobial properties. However, issues such as proteolytic sensitivity and potential high-concentration toxicity must be addressed. To fully realize LL-37's therapeutic potential against multidrug-resistant infections, future studies should focus on creating stable analogs, optimizing delivery mechanisms, and exploring synergistic combinations with existing antibiotics.
Authors
- Mahdi Hosseini Bafghi (ORCID: https://orcid.org/0000-0003-3632-3170)
- Mohammad Ali Karimi (ORCID: https://orcid.org/0000-0002-7133-5161)
- Nooshin Sadat Ghiasi
- Alireza Neshani (ORCID: https://orcid.org/0000-0001-8645-4916)
- Hosna Zare (ORCID: https://orcid.org/0000-0003-3569-1342)
Institutions
- Mashhad University of Medical Sciences (IR)
Publication Details
- Journal
- Infection Genetics and Evolution
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.meegid.2025.105853
- Citations
- 4
- Primary Topic
- Antimicrobial Peptides and Activities
- Type
- article
- Field-Weighted Citation Impact
- 4.73