Novel <i>NOTCH3</i> alteration expanding the molecular spectrum of pericytic tumours: report of two cases
Our findings suggest that NOTCH3 ITDs represent a novel oncogenic mechanism in pericytic tumour pathogenesis, likely driving constitutive activation of the NOTCH signalling pathway. Given the potential therapeutic relevance, particularly in aggressive or life-threatening cases with CNS involvement, our findings highlight the importance of extensive molecular profiling. Targeted therapy with NOTCH inhibitors may represent a promising strategy in the management of aggressive cases of ITD-driven pericytic tumours.
Authors
- Mégane Le Quang
- Rihab Azmani
- François Le Loarer (ORCID: https://orcid.org/0000-0001-8582-9819)
- Guillaume Chotard (ORCID: https://orcid.org/0000-0003-0992-1597)
- Henri Margot (ORCID: https://orcid.org/0000-0003-1353-0716)
- Irena Antonia Ungureanu (ORCID: https://orcid.org/0000-0001-9541-0202)
- Nathalène Truffaux
- Marie Ancelle
Institutions
- Université de Bordeaux (FR)
- Inserm (FR)
- Université de Versailles Saint-Quentin-en-Yvelines (FR)
- Bordeaux Population Health (FR)
- Hôpital Pellegrin (FR)
- Hôpital Ambroise-Paré (FR)
- Institut Bergonié (FR)
Publication Details
- Journal
- Histopathology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1111/his.70051
- Primary Topic
- Cerebrovascular and genetic disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ligue Contre le Cancer