Divergent Annulation of Isoindolinone-Derived Propargyl Alcohols for the <i>peri</i> -Selective Synthesis of Spirofuran-Isoindolinones and Furanylisoindolinones
We describe a <i>peri</i>-selective synthesis of spirofuran-isoindolinones and 3-furan-2-ylisoindolinones through cascade annulation of cyclohexandiones or their surrogates with isoindolinone-derived propargyl alcohols. Using this methodology, two isoindolinone isomeric scaffolds are independently obtained in high yields.
Authors
- Dong‐Rong Xiao (ORCID: https://orcid.org/0000-0003-4610-1969)
- Zhehan Yang (ORCID: https://orcid.org/0000-0001-6249-0170)
- Qun‐Li Luo (ORCID: https://orcid.org/0000-0002-9724-5674)
- Yan Yu (ORCID: https://orcid.org/0009-0004-0898-7951)
- Yue Zhou (ORCID: https://orcid.org/0000-0002-7797-4001)
- Ligang Bai
Institutions
- Southwest University (CN)
- Kunming Institute of Precious Metals (CN)
- Chongqing Municipal Government (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1021/acs.orglett.5c04509
- Primary Topic
- Synthesis and pharmacology of benzodiazepine derivatives
- Type
- article
- Field-Weighted Citation Impact
- 0.00