Flow-cytometric analysis of immune cell populations in patients with depression: relationship with depression severity and electroconvulsive therapy therapeutic outcomes
Overall, these results demonstrate that flow cytometry is useful for immune profiling to identify altered adaptive immune features in depression and potential biomarkers of ECT response. In particular, changes in classical monocytes and effector memory T cells were associated with treatment response in patients with unipolar depression.
Authors
- Andrew Harkin (ORCID: https://orcid.org/0000-0001-9734-216X)
- Clare Sheridan
- Aoife M. O’Rourke (ORCID: https://orcid.org/0000-0001-9882-2907)
- Jean M. Fletcher (ORCID: https://orcid.org/0000-0002-0670-6659)
- Declan M. McLoughlin (ORCID: https://orcid.org/0000-0003-4574-2799)
- Karen M. Ryan (ORCID: https://orcid.org/0000-0002-9264-8757)
- Barry Moran (ORCID: https://orcid.org/0000-0002-8243-1079)
- Mayra García Quintana
Institutions
- Trinity College Dublin (IE)
- St. Patrick's Hospital (IE)
Publication Details
- Journal
- Frontiers in Cellular Neuroscience
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fncel.2025.1693999
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00