Inhibition of Histone Methyltransferase G9a Activates Autophagy and Provides Protection in Dry Eye Disease
G9a downregulation confers protective effects in DED by promoting autophagy. Mechanistically, G9a inhibition enhances autophagy through the reduction of H3K9me2-mediated transcriptional silencing of ATG7. This G9a-autophagy axis offers significant protection against DED in both in vitro and in vivo models.
Authors
- Kai Hu (ORCID: https://orcid.org/0009-0001-6910-9413)
- Jiaxuan Jiang (ORCID: https://orcid.org/0000-0002-7889-5209)
- Qi Zhang (ORCID: https://orcid.org/0000-0001-9916-8919)
- Di Zhang (ORCID: https://orcid.org/0000-0002-0228-5244)
- Yiran Chu
- Boda Li (ORCID: https://orcid.org/0000-0002-6698-8635)
- Huayong Zhang (ORCID: https://orcid.org/0000-0003-0125-2755)
- Yun Tang (ORCID: https://orcid.org/0000-0002-8807-5239)
- Zeying Chen
Institutions
- Nanjing Drum Tower Hospital (CN)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1167/iovs.66.14.52
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00