Inflammatory proteins as acute biomarkers of post-traumatic epilepsy
Based on our findings, serum levels of HMGB1, MMP-9, IL-6, IL-8 and IL-10 measured at early time points after TBI may not serve as sensitive biomarkers of PTE. However, a faster decline in IL-6 levels in the non-PTE groups suggests a more rapid resolution of inflammation among patients who do not develop PTE, supporting the role of neuroinflammatory mechanisms in epileptogenesis. The potential of IL-6's temporal profile as a biomarker of PTE warrants further exploration.
Authors
- Hild Flatmark Sødal (ORCID: https://orcid.org/0000-0002-2179-0633)
- Eirik Helseth (ORCID: https://orcid.org/0000-0001-5758-6485)
- Valentina Bonetto
- Laura Pasetto (ORCID: https://orcid.org/0000-0003-0319-4448)
- Pavel Klein (ORCID: https://orcid.org/0000-0001-7244-3722)
- Robert McCarter
- Silvia Balosso (ORCID: https://orcid.org/0000-0001-6712-8023)
- Annamaria Vezzani (ORCID: https://orcid.org/0000-0003-0573-6175)
- Stefano Fabrizio Columbro
- Erik Taubøll
Institutions
- Oslo University Hospital (NO)
- Children's National (US)
- University of Oslo (NO)
- Mario Negri Institute for Pharmacological Research (IT)
- Mid Atlantic Epilepsy and Sleep Center (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3389/fneur.2025.1720112
- Primary Topic
- Epilepsy research and treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- Citizens United for Research in Epilepsy
- University of Washington
- Virginia Commonwealth University
- Universitetet i Oslo
- Masarykova Univerzita
- University of California, Davis