Comparing survival with vitamin K antagonists, low-molecular-weight heparin, and direct oral anticoagulants in patients with cancer—a systematic review and meta-analysis
The use of VKA was associated with lower mortality than non-VKA anticoagulation in patients with cancer in observational studies but not in randomized trials. The analysis was limited by high heterogeneity, which must be considered when interpreting results.
Authors
- Jeffrey I. Zwicker (ORCID: https://orcid.org/0000-0001-5810-6893)
- Rushad Patell (ORCID: https://orcid.org/0000-0002-8426-3398)
- Justine Ryu
- Anika Patel (ORCID: https://orcid.org/0000-0002-5076-6771)
- Thita Chiasakul (ORCID: https://orcid.org/0000-0002-0443-1751)
- Kevin J Barnum
- Megan McNichol (ORCID: https://orcid.org/0000-0002-6990-3676)
- Vasiliki Xirou (ORCID: https://orcid.org/0000-0001-6370-9701)
- Jason Gusdorf (ORCID: https://orcid.org/0000-0002-4357-5942)
- Rishabh Singh (ORCID: https://orcid.org/0000-0002-8950-4277)
- Maria Fernanda Albuja Altamirano (ORCID: https://orcid.org/0000-0001-9935-2476)
Institutions
- Creighton University (US)
- Lincoln Medical Center (US)
- Mount Auburn Hospital (US)
- Thai Red Cross Society (TH)
- Beth Israel Deaconess Medical Center (US)
- Memorial Sloan Kettering Cancer Center (US)
- Harvard University (US)
- Chulalongkorn University (TH)
- Illinois College (US)
- Cornell University (US)
- King Chulalongkorn Memorial Hospital (TH)
- Yale University (US)
- Lahey Medical Center (US)
Publication Details
- Journal
- Research and Practice in Thrombosis and Haemostasis
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.rpth.2025.103268
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00