Additive-Controlled Divergent Synthesis of Amides and Ketones via Ni/Photoredox-Catalyzed Deoxygenative Functionalization of Alcohols

Amides and ketones are essential carbonyl compounds with widespread applications in pharmaceuticals, materials science, and synthetic chemistry. Herein, we present a Ni/photoredox dual-catalyzed strategy for the divergent synthesis of amides and ketones from isocyanates and alcohols. This transformation is facilitated by <i>N</i>-heterocyclic carbene (NHC)-mediated activation of alcohols and is selectively controlled by the choice of additive: NaOAc promotes amide formation, whereas <i>n</i>Bu₄NPO₄H₂ directs the reaction toward ketone synthesis. This approach offers a versatile and practical route to access amides and ketones from readily available alcohol feedstocks.