Severe multiarticular gouty tophi

Tophaceous gout is a chronic, advanced manifestation of gout, characterized by subcutaneous and periarticular deposition of monosodium urate crystals, leading to the formation of tophi. While modern urate-lowering therapies have reduced the incidence of tophaceous disease, it still occurs in patients with delayed diagnosis, nonadherence to treatment, or inadequate medical follow-up. We present the case of a 62-year-old male admitted with an acute ischemic stroke, which led to the incidental discovery of his advanced, untreated tophaceous disease. He was found to have extensive tophaceous involvement of multiple joints and soft tissues, including disfiguring nodules on the hands, elbows, and forearms. Management of tophaceous gout hinges on sustained urate-lowering therapy and careful monitoring to prevent irreversible joint damage. This report underscores the long-term consequences of untreated gout and the critical importance of early diagnosis and lifelong adherence to medical therapy.

Authors

Institutions

Publication Details

Journal
Medical Reports
Published
2025-11-20
DOI
https://doi.org/10.1016/j.hmedic.2025.100390
Primary Topic
Gout, Hyperuricemia, Uric Acid
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Severe multiarticular gouty tophi

Farzana Hoque, Krislyn Cardoza
Medical Reports
Gout, Hyperuricemia, Uric Acid
article

Severe multiarticular gouty tophi

Farzana Hoque, Krislyn Cardoza
article en

Abstract

Tophaceous gout is a chronic, advanced manifestation of gout, characterized by subcutaneous and periarticular deposition of monosodium urate crystals, leading to the formation of tophi. While modern urate-lowering therapies have reduced the incidence of tophaceous disease, it still occurs in patients with delayed diagnosis, nonadherence to treatment, or inadequate medical follow-up. We present the case of a 62-year-old male admitted with an acute ischemic stroke, which led to the incidental discovery of his advanced, untreated tophaceous disease. He was found to have extensive tophaceous involvement of multiple joints and soft tissues, including disfiguring nodules on the hands, elbows, and forearms. Management of tophaceous gout hinges on sustained urate-lowering therapy and careful monitoring to prevent irreversible joint damage. This report underscores the long-term consequences of untreated gout and the critical importance of early diagnosis and lifelong adherence to medical therapy.

Medical ReportsVol. 14
Saint Louis University (US)
Openalex Percentile: Top 58%
Gout, Hyperuricemia, Uric Acid
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.