Butyrate-preconditioned human adipose-derived stem cell-conditioned medium enhances myocardial perfusion after infarction
Butyrate preconditioning enhanced the paracrine activity of ASC-CM and was associated with improved myocardial perfusion in a rat model. These findings suggest that butyrate may augment the ASC secretome function. Potential mechanisms such as endothelial repair, angiogenesis, and immune modulation remain hypothetical and require further validation in future studies.
Authors
- Kenjiro Matsumoto (ORCID: https://orcid.org/0000-0003-3315-1203)
- Shinji Kobuchi (ORCID: https://orcid.org/0000-0002-4694-4651)
- Masayuki Tsujimoto (ORCID: https://orcid.org/0000-0003-1325-8329)
- Hidekazu Kawashima (ORCID: https://orcid.org/0000-0003-4078-4199)
- Kazuyuki Takata (ORCID: https://orcid.org/0000-0001-5332-1279)
- Shohei Hamada (ORCID: https://orcid.org/0000-0003-4352-0017)
- Ryuzaburo Kagawa
- M Matsuzawa
- Koki Harada
- Wan-Tseng Hsu (ORCID: https://orcid.org/0000-0001-6358-999X)
- Junko Watanabe (ORCID: https://orcid.org/0000-0001-8024-108X)
- Kaneyasu Nishimura (ORCID: https://orcid.org/0000-0002-5582-3341)
- Yuki Toda
Institutions
- Doshisha University (JP)
- National Taiwan University (TW)
- Kyoto Pharmaceutical University (JP)
- Doshisha Women's College of Liberal Arts (JP)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.reth.2025.11.007
- Primary Topic
- Cardiac Fibrosis and Remodeling
- Type
- article
- Field-Weighted Citation Impact
- 0.00