Pre‐existing CD95‐based Temra immunity in patients with recurrent/metastatic nasopharyngeal carcinoma predicts response and hyperprogression to dual PD‐L1 and TGFβ inhibition

Authors

Kenneth Sik Kwan Chan
Chi‐Leung Chiang (ORCID: https://orcid.org/0000-0002-9836-6478)
Wei Dai (ORCID: https://orcid.org/0000-0002-5558-0685)
Jeffrey Yan Ho Lau
Tai‐Chung Lam (ORCID: https://orcid.org/0000-0001-7354-2271)
Ngar Woon Kam
Dora L.�W. Kwong (ORCID: https://orcid.org/0000-0002-1304-2854)
Cho Yiu Lau
Victor Lee Ho Fun

Institutions

Chinese University of Hong Kong (HK)
University of Hong Kong - Shenzhen Hospital (CN)
University of Hong Kong (HK)

Publication Details

Journal: Clinical and Translational Medicine
Published: 2025-11-01
DOI: https://doi.org/10.1002/ctm2.70535
Primary Topic: Immunotherapy and Immune Responses
Type: article
Field-Weighted Citation Impact: 0.00

Funders

Health and Medical Research Fund

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article

Pre‐existing CD95‐based Temra immunity in patients with recurrent/metastatic nasopharyngeal carcinoma predicts response and hyperprogression to dual PD‐L1 and TGFβ inhibition

Kenneth Sik Kwan Chan, Chi‐Leung Chiang, Wei Dai, Jeffrey Yan Ho Lau et al.

Nov 1, 2025

Clinical and Translational Medicine

Immunotherapy and Immune Responses

article

Pre‐existing CD95‐based Temra immunity in patients with recurrent/metastatic nasopharyngeal carcinoma predicts response and hyperprogression to dual PD‐L1 and TGFβ inhibition

Kenneth Sik Kwan Chan, Chi‐Leung Chiang, Wei Dai, Jeffrey Yan Ho Lau, Tai‐Chung Lam, Ngar Woon Kam, Dora L.�W. Kwong, Cho Yiu Lau, Victor Lee Ho Fun

November 1, 2025article en

Abstract

No abstract available for this paper.

Clinical and Translational MedicineVol. 15(11)

Chinese University of Hong Kong (HK), University of Hong Kong - Shenzhen Hospital (CN), University of Hong Kong (HK)

Health and Medical Research Fund

Openalex Percentile: Top 62%

Immunotherapy and Immune Responses

DOI Open Access PDF OpenAlex

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