Impact of treatment sequence and dose response on outcomes in locally advanced pancreatic cancer treated with hypofractionated proton beam therapy using simultaneous integrated boost technique
This largest to-date study on PBT for LAPC suggests that hypofractionated SIB-PBT could be a safe and effective local treatment for LAPC. Favorable outcomes were observed with PBT after stable disease following induction chemotherapy, and a potential dose-response relationship was suggested. However, further prospective studies are required to validate our findings.
Authors
- Joo-Hyun Chung
- Sung Ho Moon (ORCID: https://orcid.org/0009-0009-8940-9403)
- Sang Myung Woo (ORCID: https://orcid.org/0000-0003-3786-4403)
- Jung Won Chun (ORCID: https://orcid.org/0000-0003-1964-7501)
- Yang‐Gun Suh (ORCID: https://orcid.org/0000-0001-8381-9836)
- Tae Hyun Kim (ORCID: https://orcid.org/0000-0003-1053-8958)
- Min Hee Lee (ORCID: https://orcid.org/0000-0002-7403-7274)
- Sang Soo Kim (ORCID: https://orcid.org/0000-0002-9687-8357)
- Sung Uk Lee (ORCID: https://orcid.org/0000-0003-2213-706X)
- Woo‐Jin Lee (ORCID: https://orcid.org/0000-0003-2115-6701)
- Sang-Jae Park
- Sung-Sik HAN
Institutions
- National Cancer Center (US)
- National Cancer Center (KR)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.radonc.2025.111295
- Primary Topic
- Pancreatic and Hepatic Oncology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00