Immunogenicity of JN.1 and KP.2 COVID-19 mRNA vaccines against emerging SARS-CoV-2 variants
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) continues to evolve five years after the initial outbreak. Although mRNA vaccines encoding the JN.1 and KP.2 Spike proteins were authorized in fall 2024, it remains unclear whether vaccine updates will be necessary for variants containing antigenically closely related Spike proteins. In this study, we evaluated the immunogenicity of JN.1 and KP.2 mRNA boosters in participants from Germany and the United States, respectively. Both vaccines induced robust and similar neutralizing antibody responses against JN.1, KP.2, and other globally relevant variants such as LP.8.1.1 and NB.1.8.1. These data suggest that updating the vaccine formulation to closely related strains will likely offer only modest additional benefits against currently circulating variants.
Authors
- Annika Rössler (ORCID: https://orcid.org/0000-0002-5298-0288)
- Ai-ris Yonekura Collier (ORCID: https://orcid.org/0000-0002-8539-3960)
- Georg M. N. Behrens (ORCID: https://orcid.org/0000-0003-3111-621X)
- Juliana Pereira (ORCID: https://orcid.org/0009-0004-0505-6051)
- I. McConnell
- Ninaad Lasrado (ORCID: https://orcid.org/0000-0001-6762-2654)
- Erica N. Borducchi
- Christine Happle (ORCID: https://orcid.org/0000-0003-0096-3272)
- Katherine Molloy
- Metodi V. Stankov (ORCID: https://orcid.org/0000-0003-3001-2478)
- Dan H. Barouch (ORCID: https://orcid.org/0000-0001-5127-4659)
- Katherine McMahan (ORCID: https://orcid.org/0000-0002-3933-0539)
- Jinyan Liu
- Krishna Shah
- Liping Wang (ORCID: https://orcid.org/0000-0003-3049-9917)
- Ruoran Guan
- Alexandra Dopfer‐Jablonka (ORCID: https://orcid.org/0000-0001-7129-100X)
- R. K. Bhowmik
- Bridget Wixted
Institutions
- Beth Israel Deaconess Medical Center (US)
- Harvard University (US)
- Medizinische Hochschule Hannover (DE)
- German Center for Infection Research (DE)
Publication Details
- Journal
- Vaccine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.vaccine.2025.127997
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79