Integrated bioinformatics analysis to elucidate cellular communication in the microenvironment of breast cancer
In the tumor microenvironment of breast cancer, intercellular communication pairs of different cell types and molecules can exacerbate the development of breast cancer. among them, through the present study, we found that CXCL12-CXCR4 and FGF7-FGFR1 are the most important. Also, most significantly differentially expressed genes including CHRDL1, SCARA5, LYVE1, PI16, and SAA2 seemed to play a critical role in these mechanisms and immune cell infiltration, shaping the TME of BC.
Authors
- Xingong Zhang
- Zhijian Zha (ORCID: https://orcid.org/0009-0005-4636-7363)
- Qi Wang (ORCID: https://orcid.org/0000-0002-4031-7307)
- Hua Li (ORCID: https://orcid.org/0000-0002-6389-6065)
- Man Wang (ORCID: https://orcid.org/0000-0002-7364-7994)
- Danfeng Zhang (ORCID: https://orcid.org/0000-0002-6273-3395)
- Mengjia Zhao
Institutions
- Jiangsu University (CN)
- Hubei University of Medicine (CN)
- Hubei University of Chinese Medicine (CN)
- Affiliated Hospital of Jiangsu University (CN)
- Taihe Hospital (CN)
- Affiliated Hospital of Youjiang Medical University for Nationalities (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1007/s12672-025-03859-4
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00