Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci
We found extensive overlap in genetic architecture between ASD, loneliness, and social isolation, with bidirectional effects. By leveraging data for ASD and social traits, we identified 12 novel ASD related genetic loci implicating several genes, thereby elucidating potential pathways underlying their shared genetic architecture.
Authors
- Saira Jameela Hübenette (ORCID: https://orcid.org/0000-0001-6947-0885)
- Olav B. Smeland (ORCID: https://orcid.org/0000-0002-3761-5215)
- Sigrun Hope (ORCID: https://orcid.org/0000-0003-0115-5285)
- Shahram Bahrami (ORCID: https://orcid.org/0000-0002-8179-2788)
- Ida E. Sønderby (ORCID: https://orcid.org/0000-0001-7297-7855)
- Aihua Lin (ORCID: https://orcid.org/0000-0002-1157-7249)
- Daniel Quintana (ORCID: https://orcid.org/0000-0003-2876-0004)
- Alexey A. Shadrin (ORCID: https://orcid.org/0000-0002-7467-250X)
- Terje Nærland (ORCID: https://orcid.org/0000-0001-9175-4286)
- Srdjan Djurovic (ORCID: https://orcid.org/0000-0002-8140-8061)
- Guy Hindley (ORCID: https://orcid.org/0000-0003-1666-4701)
- Anett Kaale (ORCID: https://orcid.org/0000-0002-2680-3384)
- Linn Rødevand (ORCID: https://orcid.org/0000-0001-5967-6601)
- Weiqiu Cheng (ORCID: https://orcid.org/0000-0003-4001-8662)
- Nadine Parker (ORCID: https://orcid.org/0000-0002-8369-0152)
- Kevin S. O’Connell (ORCID: https://orcid.org/0000-0002-6865-8795)
- Oleksandr Frei (ORCID: https://orcid.org/0000-0002-6427-2625)
Institutions
- Oslo University Hospital (NO)
- King's College London (GB)
- University of Oslo (NO)
- Centre Hospitalier de l'Agglomération de Nevers (FR)
- Geohabitat (Spain) (ES)
- University of Bergen (NO)
Publication Details
- Journal
- Psychiatric Genetics
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1097/ypg.0000000000000406
- Citations
- 1
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 1.43