Small cell lung cancer transdifferentiation: not a negligible phenomenon
Several molecular mechanisms that can drive SCLC transdifferentiation have been identified. The treatment of transdifferentiated SCLC remains a significant challenge, although promising new strategies are currently under investigation. This review summarizes the current understanding of SCLC transdifferentiation.
Authors
- Lilla Horváth (ORCID: https://orcid.org/0000-0002-2089-1440)
- Judit Berta (ORCID: https://orcid.org/0000-0003-3751-6716)
- Anita Horváth-Rózsás
- Balázs Döme (ORCID: https://orcid.org/0000-0001-8799-8624)
- Clemens Aigner (ORCID: https://orcid.org/0000-0002-7787-991X)
- Kristiina Boettiger (ORCID: https://orcid.org/0009-0001-0602-5597)
- Zsolt Megyesfalvi
Institutions
- Semmelweis University (HU)
- Lund University (SE)
- Comprehensive Cancer Center Vienna (AT)
- National Institute of Oncology (HU)
- Országos Korányi Tbc és Pulmonológiai Intézet (HU)
- Medical University of Vienna (AT)
Publication Details
- Journal
- Current Opinion in Oncology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1097/cco.0000000000001205
- Primary Topic
- Lung Cancer Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00