Hepatic soluble epoxide hydrolase mediates osteoclastogenesis by suppressing the Nrf2 signaling pathway: a novel mechanism of redox imbalance in osteoporosis
This study reveals, for the first time, a novel regulatory mechanism of bone metabolism mediated by the "liver-bone axis." Liver-derived sEH remotely modulates the Nrf2-ARE signaling pathway in bone tissue by controlling circulating levels of 14,15-EET, 14,15-DHET, and pro-inflammatory cytokines, thereby influencing osteoclast differentiation and bone homeostasis. These findings provide new insights into the pathogenesis of osteoporosis.
Authors
- Ji‐chun Zhang (ORCID: https://orcid.org/0000-0001-6035-6867)
- Xiu Hong Yang (ORCID: https://orcid.org/0000-0002-7537-482X)
- Hongli Chang (ORCID: https://orcid.org/0000-0002-5371-8855)
- Hongguang Chang
- Peipei Li (ORCID: https://orcid.org/0000-0001-9142-448X)
- Bo Liu (ORCID: https://orcid.org/0009-0007-2127-4894)
- Xuenan Wang (ORCID: https://orcid.org/0009-0008-5587-5169)
- Wubing He (ORCID: https://orcid.org/0009-0002-5187-6339)
Institutions
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Free Radical Biology and Medicine
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.freeradbiomed.2025.11.036
- Citations
- 1
- Primary Topic
- Eicosanoids and Hypertension Pharmacology
- Type
- article
- Field-Weighted Citation Impact
- 1.11