Escitalopram normalizes decreased left inferior frontal gyrus activation in social anxiety disorder during self-referential processing
SAD may be associated with decreased activation of the left inferior frontal gyrus to negative self-referential social cues. Escitalopram may normalize such activation. As left inferior frontal gyrus has been linked to inner speech while working on self-reflection tasks, the increased activation might relate to reappraising negative social cues.
Authors
- Jesper Ekelund (ORCID: https://orcid.org/0000-0003-1859-5180)
- Rasmus Rinne
- Erkki Isometsä (ORCID: https://orcid.org/0000-0001-5956-2399)
- Tuukka T. Raij (ORCID: https://orcid.org/0000-0002-9834-5570)
- Roope Heikkilä (ORCID: https://orcid.org/0000-0002-2125-577X)
- Emma Komulainen (ORCID: https://orcid.org/0000-0001-6757-6336)
Institutions
- University of Helsinki (FI)
- Helsinki University Hospital (FI)
- Hospital District of Helsinki and Uusimaa (FI)
- Aalto University (FI)
Publication Details
- Journal
- Psychiatry Research Neuroimaging
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.pscychresns.2025.112092
- Primary Topic
- Neural and Behavioral Psychology Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00