Osteochondral knee joint lesion treated with an aragonite-based scaffold. 12-year follow-up of the world's first implantation: Case report

Articular surface lesions, which include chondral and osteochondral defects, are debilitating and favor the development of osteoarthritis. The long-term follow-up of the world's first case of implantation of an aragonite-based scaffold (Agili-C™, from CartiHeal) in a chronic post-traumatic osteochondral knee joint lesion (International Cartilage Repair Society (ICRS) grade IV, size 2 ​cm<sup>2</sup>) was presented. Over a decade after implantation, the treatment results remained stable, the patient was fully satisfied, and was able to resume his preinjury activities. Despite the partial meniscectomy of the medial meniscus, the degenerative process was successfully contained, with only subtle osteophytes and mild narrowing of the medial compartment. In addition, radiologic monitoring of the restored bone and cartilage tissue showed successful and durable results. STUDY DESIGN: Case-report (level of evidence: V).

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Publication Details

Journal
Journal of ISAKOS Joint Disorders & Orthopaedic Sports Medicine
Published
2025-11-20
DOI
https://doi.org/10.1016/j.jisako.2025.101040
Primary Topic
Knee injuries and reconstruction techniques
Type
article
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article

Osteochondral knee joint lesion treated with an aragonite-based scaffold. 12-year follow-up of the world's first implantation: Case report

Elizaveta Kon, Matej Drobnič, Matic Kolar, Dror Robinson et al.
Journal of ISAKOS Joint Disorders & Orthopaedic Sports Medicine
Knee injuries and reconstruction techniques
article

Osteochondral knee joint lesion treated with an aragonite-based scaffold. 12-year follow-up of the world's first implantation: Case report

Elizaveta Kon, Matej Drobnič, Matic Kolar, Dror Robinson, Nir Altschuler
article en

Abstract

Articular surface lesions, which include chondral and osteochondral defects, are debilitating and favor the development of osteoarthritis. The long-term follow-up of the world's first case of implantation of an aragonite-based scaffold (Agili-C™, from CartiHeal) in a chronic post-traumatic osteochondral knee joint lesion (International Cartilage Repair Society (ICRS) grade IV, size 2 ​cm<sup>2</sup>) was presented. Over a decade after implantation, the treatment results remained stable, the patient was fully satisfied, and was able to resume his preinjury activities. Despite the partial meniscectomy of the medial meniscus, the degenerative process was successfully contained, with only subtle osteophytes and mild narrowing of the medial compartment. In addition, radiologic monitoring of the restored bone and cartilage tissue showed successful and durable results. STUDY DESIGN: Case-report (level of evidence: V).

Journal of ISAKOS Joint Disorders & Orthopaedic Sports MedicineVol. 16
Humanitas University (IT), Rabin Medical Center (IL), Ljubljana University Medical Centre (SI), Lev Hasharon Hospital (IL), IRCCS Humanitas Research Hospital (IT)
Openalex Percentile: Top 46%
Knee injuries and reconstruction techniques
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Osteochondral knee joint lesion treated with an aragonite-based scaffold. 12-year follow-up of the world's first implantation: Case report — Elizaveta Kon, Matej Drobnič, et al. · Journal of ISAKOS Joint Disorders & Orthopaedic Sports Medicine (2025) | TGRS Research Map | TGRS