Immunological role of IL-25 on gut-dwelling helminths

Interleukin-25 (IL-25) is a crucial cytokine in coordinating type 2 immunity against gut-dwelling helminths. IL-25 is produced by a variety of cells, including epithelial and immune cells, and primarily stimulates Th2-type immune responses characterized by the release of IL-13, IL-5, and IL-4, which play a vital role in eosinophilia induction, goblet cell hyperplasia, and IgE synthesis. This review critically examines IL-25's role in maintaining intestinal barrier integrity and modulating regulatory immune responses. This review addresses how IL-25 integrates signals from the epithelial interface, immune cells, and gut microbiota to calibrate appropriate host defense while preventing pathological inflammation. Furthermore, this paper presents recent evidence supporting IL-25's therapeutic potential, both as a potential adjuvant therapy to enhance parasite clearance and as a modulator of inflammatory conditions where type 2 immunity proves deficient.

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Publication Details

Journal
Infection Genetics and Evolution
Published
2025-11-20
DOI
https://doi.org/10.1016/j.meegid.2025.105856
Primary Topic
Parasites and Host Interactions
Type
article
Field-Weighted Citation Impact
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Immunological role of IL-25 on gut-dwelling helminths

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Immunological role of IL-25 on gut-dwelling helminths

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article en

Abstract

Interleukin-25 (IL-25) is a crucial cytokine in coordinating type 2 immunity against gut-dwelling helminths. IL-25 is produced by a variety of cells, including epithelial and immune cells, and primarily stimulates Th2-type immune responses characterized by the release of IL-13, IL-5, and IL-4, which play a vital role in eosinophilia induction, goblet cell hyperplasia, and IgE synthesis. This review critically examines IL-25's role in maintaining intestinal barrier integrity and modulating regulatory immune responses. This review addresses how IL-25 integrates signals from the epithelial interface, immune cells, and gut microbiota to calibrate appropriate host defense while preventing pathological inflammation. Furthermore, this paper presents recent evidence supporting IL-25's therapeutic potential, both as a potential adjuvant therapy to enhance parasite clearance and as a modulator of inflammatory conditions where type 2 immunity proves deficient.

Infection Genetics and EvolutionVol. 136
Institut national de recherche en sciences et technologies du numérique (FR), University of Gondar (ET), Debre Markos University (ET), Mejiro University (JP)
Openalex Percentile: Top 63%
Parasites and Host Interactions
DOIOpen Access PDFOpenAlex
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