Serum p-Cresol and 7-HOCA Levels and Fatty Acid and Purine Metabolism Are Associated with Survival, Progression, and Molecular Classification in GB—Serum Proteome and Metabolome Analysis Pre vs. Post Up-Front Chemoirradiation
Serum-based fatty acid and purine metabolism pathways are associated with OS and PFS in GB. 7-HOCA and p-cresol emerged as potential biomarkers linked to treatment response and molecular subtype. These findings support further investigation of noninvasive biospecimens for clinically actionable biomarkers in GB.
Authors
- Theresa Cooley Zgela
- Mary Sproull (ORCID: https://orcid.org/0000-0002-6962-0166)
- Kevin Camphausen (ORCID: https://orcid.org/0000-0002-0450-4877)
- Andra Krauze (ORCID: https://orcid.org/0000-0003-1634-6877)
- Shreya Chappidi (ORCID: https://orcid.org/0000-0001-7042-5766)
- Yingdong Zhao (ORCID: https://orcid.org/0000-0002-8514-0293)
- M. Li (ORCID: https://orcid.org/0009-0002-7053-5652)
- Megan Mackey
Institutions
- University of Cambridge (GB)
- National Cancer Institute (US)
- Center for Cancer Research (US)
Publication Details
- Journal
- Current Oncology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.3390/curroncol32110650
- Primary Topic
- Cancer, Hypoxia, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health