γ-Aminobutyric acid and glutamate dysregulation in the dorsolateral prefrontal cortex of adolescents with first-episode major depressive disorder and the modulatory effects of repetitive transcranial magnetic stimulation
FEA-MDD involves prefrontal GABA+/Glx dysregulation, and rTMS may aid in restoring neurotransmitter balance within the DLPFC. This study adds to the expanding body of evidence supporting the application of targeted neurochemical modulation in the treatment of FEA-MDD, while also providing insights into potential intervention mechanisms.
Authors
- Xiaoxiao Ma (ORCID: https://orcid.org/0000-0001-8661-5660)
- Jing Zhang (ORCID: https://orcid.org/0000-0002-1678-5688)
- Wenjing Huang (ORCID: https://orcid.org/0000-0002-5791-0369)
- Lili Xu (ORCID: https://orcid.org/0000-0002-5395-2924)
- Songhong Yue
- Laiyang Ma
- Jun Wang (ORCID: https://orcid.org/0009-0002-7492-230X)
- Yuhui Xiong
- Wanjun Hu
Institutions
- General Electric (Spain) (ES)
- Changzhi Medical College (CN)
- Institute of Molecular Functional Materials (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Psychoradiology
- Published
- 2025-11-19
- DOI
- https://doi.org/10.1093/psyrad/kkaf034
- Primary Topic
- Transcranial Magnetic Stimulation Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Lanzhou University
- Science and Technology Program of Gansu Province