Post-transcriptional modifications on tRNA fragments confer functional changes to high-density lipoproteins in atherosclerosis
Results support a model in which HDL-delivered m<sup>1</sup>A-HDL-tDRs regulate immune signaling, macrophage activation, and pro-inflammatory sub-phenotypes within the atherosclerotic lesion.
Authors
- J. Jeffrey Carr (ORCID: https://orcid.org/0000-0002-4398-8237)
- Kasey C. Vickers (ORCID: https://orcid.org/0000-0001-5643-3102)
- Quanhu Sheng (ORCID: https://orcid.org/0000-0001-8951-9295)
- Elizabeth M. Semler (ORCID: https://orcid.org/0000-0002-0271-2728)
- Mark Castleberry (ORCID: https://orcid.org/0000-0002-7916-5451)
- Philip J. Kingsley (ORCID: https://orcid.org/0000-0002-5470-4340)
- Clark Massick (ORCID: https://orcid.org/0009-0009-4418-2006)
- Amanda C. Doran (ORCID: https://orcid.org/0000-0002-1576-6274)
- MacRae F. Linton (ORCID: https://orcid.org/0000-0002-9277-0453)
- Lawrence J. Marnett (ORCID: https://orcid.org/0000-0002-7834-6285)
- Danielle L. Michell (ORCID: https://orcid.org/0000-0002-2048-4191)
- Marisol Ramirez
Institutions
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
Publication Details
- Journal
- Atherosclerosis
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.atherosclerosis.2025.120584
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00