Whole-genome sequence analysis of cefiderocol-resistant E. coli and Klebsiella pneumoniae isolates from cefiderocol treatment-naïve patients
Cefiderocol (FDC) is regarded as a reserved therapeutic option for serious CRE infections. In an earlier study, we had reported a 9.9 % FDC resistance in CRE isolates. In the present study, we are reporting the whole genome sequencing analysis findings of two FDC-resistant CRE (One E. coli and one K. pneumoniae). PBP3 insertions and mutations in the siderophore receptor cirA were the primary drivers of FDC resistance in E. coli. In K. pneumoniae, there was intact porin and a single copy of bla<sub>NDM-5</sub>, and a combination of β-lactamase and carbapenem resistance genes, including bla<sub>TEM- 1B</sub>, bla<sub>CTX-M-15,</sub>bla<sub>NDM-5</sub> and bla<sub>OXA-181</sub>.
Authors
- Bijayini Behera
- Naveen Kumar Devanga Ragupathi (ORCID: https://orcid.org/0000-0001-8667-7132)
- Gayatree Nayak
Institutions
- All India Institute of Medical Sciences Bhubaneswar (IN)
Publication Details
- Journal
- Indian Journal of Medical Microbiology
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.ijmmb.2025.101025
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00