Association of hypertension and genetic variants in MYH9 and BMPR1B with increased proteinuria in sickle cell disease
Increased total proteinuria is highly prevalent in this young cohort, indicating early onset of kidney damage. Relative systemic hypertension is a major modifiable risk factor, underscoring the need for rigorous blood pressure control. The instability of the initial genetic signal for MYH9-rs4821469, coupled with its strong linkage disequilibrium with APOL1, suggests that the observed association is likely confounded by ungenotyped APOL1 variants. This highlights the critical importance of including APOL1 analysis in future SCN genetic studies in African-ancestry populations.
Authors
- Rokhaya Dione
- Moussa Seck (ORCID: https://orcid.org/0000-0002-0561-6707)
- El Hadj Ousmane Sene
- Pape Matar Kandji
- Khuthala Mnika (ORCID: https://orcid.org/0000-0002-8461-1372)
- Serigne Saliou Mbacke
- Ibrahima Diagne (ORCID: https://orcid.org/0000-0003-0598-7281)
- Nènè Oumou Kesso Barry (ORCID: https://orcid.org/0009-0005-6311-7841)
- Papa Madièye Guéye (ORCID: https://orcid.org/0000-0003-4230-2309)
- Ambroise Wonkam (ORCID: https://orcid.org/0000-0003-1420-9051)
- El Hadji Malick Ndour (ORCID: https://orcid.org/0000-0002-0290-8675)
- Saliou Diop (ORCID: https://orcid.org/0000-0002-2354-3839)
- Rokhaya Ndiaye Diallo (ORCID: https://orcid.org/0000-0002-4287-9178)
- Coumba Kamby (ORCID: https://orcid.org/0009-0000-9524-7476)
- Aynina Cissé (ORCID: https://orcid.org/0009-0001-1038-260X)
- Victoria Nembaware (ORCID: https://orcid.org/0000-0001-7966-4042)
- Jean Pascal Demba Diop
- Moustapha Djité (ORCID: https://orcid.org/0009-0001-8200-7112)
- Indou Déme Ly
- Philomène Lopez Sall
- Fatou Guèye Tall
- Mara Sokhna
Institutions
- National Health Laboratory Service (ZA)
- Université Gaston Berger (SN)
- Johns Hopkins University (US)
- University of Cape Town (ZA)
- University of the Witwatersrand (ZA)
- Johns Hopkins Medicine (US)
- Centre Hospitalier National Universitaire de Fann (SN)
Publication Details
- Journal
- Clinical Biochemistry
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.clinbiochem.2025.111058
- Primary Topic
- Hemoglobinopathies and Related Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00