Abnormal <scp>RH</scp> antigen expression in myeloid malignancies with <scp> <i>MPL</i> </scp> mutation, <scp> <i>CSF3R</i> </scp> mutation, or 1p deletion: Evidence of two distinct mechanisms

CN-LOH of chromosome 1p, resulting in homozygosity for the MPL mutation, has been previously described in the literature. However, we report here for the first time a link between CN-LOH of chromosome 1p (resulting in homozygosity for the CSF3R mutation) or chromosome 1p deletion and the presence of RH phenotype abnormalities. Furthermore, no alloimmunization was observed despite increased transfusion requirements.

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Publication Details

Journal
Transfusion
Published
2025-11-20
DOI
https://doi.org/10.1111/trf.18482
Primary Topic
Myeloproliferative Neoplasms: Diagnosis and Treatment
Type
article
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article

Abnormal RH antigen expression in myeloid malignancies with MPL mutation, CSF3R mutation, or 1p deletion: Evidence of two distinct mechanisms

R Bourgeois, Olivier Nibourel, Gauthier Alluin, Elisabeth Durieux‐Roussel et al.
Transfusion
Myeloproliferative Neoplasms: Diagnosis and Treatment
article

Abnormal RH antigen expression in myeloid malignancies with MPL mutation, CSF3R mutation, or 1p deletion: Evidence of two distinct mechanisms

R Bourgeois, Olivier Nibourel, Gauthier Alluin, Elisabeth Durieux‐Roussel, Nicolas Duployez, Laure Delanoë, Ludovic Firrera
article en

Abstract

CN-LOH of chromosome 1p, resulting in homozygosity for the MPL mutation, has been previously described in the literature. However, we report here for the first time a link between CN-LOH of chromosome 1p (resulting in homozygosity for the CSF3R mutation) or chromosome 1p deletion and the presence of RH phenotype abnormalities. Furthermore, no alloimmunization was observed despite increased transfusion requirements.

TransfusionVol. 65(12)
Centre National de la Recherche Scientifique (FR), Inserm (FR), Lille’s Cardiology Hospital (FR), Immunité et Cancer (FR), Établissement Français du Sang (FR)
Openalex Percentile: Top 49%
Myeloproliferative Neoplasms: Diagnosis and Treatment
DOISourceOpenAlex
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Abnormal <scp>RH</scp> antigen expression in myeloid malignancies with <scp> <i>MPL</i> </scp> mutation, <scp> <i>CSF3R</i> </scp> mutation, or 1p deletion: Evidence of two distinct mechanisms — R Bourgeois, Olivier Nibourel, et al. · Transfusion (2025) | TGRS Research Map | TGRS