Updated Priorities for Cerebroprotection Trials
A STAIR XIII (Stroke Treatment Academic Industry Roundtable) workshop was held to discuss aspects of trials likely to have the greatest impact on detecting meaningful treatment effects of cerebroprotection in acute stroke. Intended goals for hyperacute protection should be focused on preserving penumbral tissue and delaying infarct core growth to augment the impact of reperfusion therapies. Infarct volume is a biologically and clinically meaningful surrogate imaging marker to assess the treatment effects of cerebroprotection. Lastly, clinical outcome measures for cerebroprotection should include domain-specific and patient-centered outcomes to detect clinically meaningful changes across multiple functional domains.
Authors
- Urs Fischer (ORCID: https://orcid.org/0000-0003-0521-4051)
- Johannes Boltze (ORCID: https://orcid.org/0000-0003-3956-4164)
- Theodore E. Liston (ORCID: https://orcid.org/0000-0002-0828-797X)
- Carolina M. Maier
- Opeolu Adeoye
- David S. Liebeskind (ORCID: https://orcid.org/0000-0002-5109-8736)
- Jocelyn Sutherland (ORCID: https://orcid.org/0009-0006-1258-2345)
- Johanna Maria Ospel (ORCID: https://orcid.org/0000-0003-0029-6764)
- Marc Fisher (ORCID: https://orcid.org/0000-0002-6116-475X)
- Sean I. Savitz (ORCID: https://orcid.org/0000-0003-4637-1790)
- Marcelo Borges Rocha (ORCID: https://orcid.org/0000-0003-4472-7423)
- William S. Korinek (ORCID: https://orcid.org/0000-0002-6293-1623)
- George Harston (ORCID: https://orcid.org/0000-0003-4916-5757)
- Edgar Andres Samaniego (ORCID: https://orcid.org/0000-0003-2764-2268)
- Davide Carone (ORCID: https://orcid.org/0000-0002-1646-6089)
- Bruce C.V. Campbell (ORCID: https://orcid.org/0000-0003-3632-9433)
- Pooja Kumari Khatri (ORCID: https://orcid.org/0000-0002-7344-8266)
- Paul Wechsler (ORCID: https://orcid.org/0000-0002-0314-1867)
- Patrick D. Lyden (ORCID: https://orcid.org/0000-0001-6170-4042)
- Lee H. Schwamm (ORCID: https://orcid.org/0000-0003-0592-9145)
- Liping Liu (ORCID: https://orcid.org/0000-0003-2943-055X)
- Michael D. Hill (ORCID: https://orcid.org/0000-0002-6269-1543)
- Joseph P. Broderick
- Gary Houser
- Kevin N. Sheth
- Supurna Ghosh
Institutions
- University of Iowa (US)
- University of California, Los Angeles (US)
- UCLA Health (US)
- University of Warwick (GB)
- The University of Texas Health Science Center (US)
Publication Details
- Journal
- Stroke
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1161/strokeaha.125.052147
- Citations
- 3
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 4.06