Hemocompatibility Outcomes After Aspirin Withdrawal in Long‐Term <scp>HeartMate</scp> 3 Left Ventricular Assist Device Patients on Vitamin K Antagonists

In long-term, stable HM3 recipients on VKA therapy, aspirin discontinuation did not increase HRAEs. Laboratory markers of hemolysis remained stable aside from a modest, clinically insignificant rise in HI. These findings extend randomized evidence supporting aspirin avoidance at implantation to patients with long-term HM3 support and suggest simplified antithrombotic regimens may be safe in selected HM3 patients. Larger multicenter studies with longer follow-up are warranted.

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Publication Details

Journal
Artificial Organs
Published
2025-11-20
DOI
https://doi.org/10.1111/aor.70059
Primary Topic
Mechanical Circulatory Support Devices
Type
article
Field-Weighted Citation Impact
0.00
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article

Hemocompatibility Outcomes After Aspirin Withdrawal in Long‐Term HeartMate 3 Left Ventricular Assist Device Patients on Vitamin K Antagonists

Christiane Marko, R. Moayedifar, Daniel Zimpfer, Julia Riebandt et al.
Artificial Organs
Mechanical Circulatory Support Devices
article

Hemocompatibility Outcomes After Aspirin Withdrawal in Long‐Term HeartMate 3 Left Ventricular Assist Device Patients on Vitamin K Antagonists

Christiane Marko, R. Moayedifar, Daniel Zimpfer, Julia Riebandt, Thomas Schlöglhofer, Barbara Karner, Melanie Arnreiter, Hebe Al Asadi, Christina Abd El‐Malak
article en

Abstract

In long-term, stable HM3 recipients on VKA therapy, aspirin discontinuation did not increase HRAEs. Laboratory markers of hemolysis remained stable aside from a modest, clinically insignificant rise in HI. These findings extend randomized evidence supporting aspirin avoidance at implantation to patients with long-term HM3 support and suggest simplified antithrombotic regimens may be safe in selected HM3 patients. Larger multicenter studies with longer follow-up are warranted.

Artificial Organs
Medical University of Vienna (AT)
Openalex Percentile: Top 66%
Mechanical Circulatory Support Devices
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