Unveiling macrophage-fibroblast-driven inflammatory networks mediated pan-cancer immune features by integrated single-cell and bulk RNA sequencing
This study developed a two-level gene signature framework (Hub-I.Sig, MC.Sig) for precision immunotherapy, bridging the gap between inflammation and immune resistance in cancer.
Authors
- Shu‐ou Shan (ORCID: https://orcid.org/0000-0002-6526-1733)
- Congting Wu
- Hongfang Liu (ORCID: https://orcid.org/0000-0001-5012-7278)
- Wei Gong (ORCID: https://orcid.org/0000-0001-5889-9184)
- Yi Liu (ORCID: https://orcid.org/0000-0002-8801-9317)
- Jing Li (ORCID: https://orcid.org/0000-0002-0998-2843)
- Liang Xu (ORCID: https://orcid.org/0000-0002-2700-4840)
Institutions
- Hubei University of Chinese Medicine (CN)
- Hubei University of Arts and Science (CN)
- Xiangyang Central Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1097/js9.0000000000004102
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00