Methodology of DNA extraction and sequencing from living cardiomyocytes collected by catheter in humans
This new mini-invasive technique of sampling allows to perform genetic analysis on CMs. Pending future improvements, this technique could provide new sources of human cells for research and potential mosaicism detection.
Authors
- Jean‐Michel Sénard (ORCID: https://orcid.org/0000-0001-7679-1281)
- Émeline Lhuillier (ORCID: https://orcid.org/0000-0003-2629-7773)
- Flavie Ader (ORCID: https://orcid.org/0000-0001-7891-3385)
- Estelle Gandjbakhch (ORCID: https://orcid.org/0000-0002-4846-5021)
- Filipe Pires (ORCID: https://orcid.org/0000-0003-2919-557X)
- Eric Villard (ORCID: https://orcid.org/0000-0001-9801-7297)
- Céline Galès (ORCID: https://orcid.org/0000-0002-4938-1583)
- Frédéric Martins (ORCID: https://orcid.org/0000-0002-2990-2636)
- Maxime Beneyto (ORCID: https://orcid.org/0000-0002-9897-6807)
- Céline Guilbeau‐Frugier (ORCID: https://orcid.org/0000-0003-2889-9188)
- Adeline Rollin
- Philippe Maury (ORCID: https://orcid.org/0000-0002-4800-1841)
- Anne‐Alicia Gonzalez
- Laëtitia Duboscq-Bidot (ORCID: https://orcid.org/0000-0001-6279-1408)
- Jean-José Maoret
- Jean Timnou-Bekouti
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Rangueil (FR)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- Hôpital Charles-Foix (FR)
- Université Paris 1 Panthéon-Sorbonne (FR)
Publication Details
- Journal
- Genetics in Medicine Open
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.gimo.2025.103473
- Primary Topic
- Congenital heart defects research
- Type
- article
- Field-Weighted Citation Impact
- 0.00