Provider Preferences About a Polypill for Heart Failure With Reduced Ejection Fraction: Development of a Multicenter Physician Survey Containing a Discrete Choice Experiment
HFrEF polypills have been proposed as a strategy to improve uptake of HFrEF therapies.However, prescribers' preferences around the components and design of a HFrEF polypill are unknown. This study reports a rigorous five-stage process for designing a discrete choice experiment (DCE), in which U.S. cardiologists will choose between hypothetical HFrEF polypill products with various components and features. The DCE developed through this study will directly inform future clinical trials of HFrEF polypills. By describing the systematic process for developing a DCE, this study can guide other researchers interested in developing DCEs for cardiovascular research.
Authors
- Matthew S. Durstenfeld (ORCID: https://orcid.org/0000-0002-7612-3352)
- Matthew D. Hickey (ORCID: https://orcid.org/0000-0001-8913-1602)
- Paul A. Heidenreich (ORCID: https://orcid.org/0000-0001-7730-8490)
- Colette DeJong (ORCID: https://orcid.org/0000-0003-0514-3193)
- Elvin Geng (ORCID: https://orcid.org/0000-0002-0825-1424)
- Blake J. Angell (ORCID: https://orcid.org/0000-0002-7188-7740)
- Priscilla Y. Hsue (ORCID: https://orcid.org/0000-0002-3427-6043)
- Charles W. Goss (ORCID: https://orcid.org/0000-0003-2682-7316)
- Mark D. Huffman (ORCID: https://orcid.org/0000-0001-7412-2519)
- Alexander T. Sandhu (ORCID: https://orcid.org/0000-0003-3208-1143)
- Mansi Agarwal (ORCID: https://orcid.org/0000-0002-0367-7733)
- Anubha Agarwal (ORCID: https://orcid.org/0000-0002-7090-5601)
- Justin C. Chen (ORCID: https://orcid.org/0000-0001-6858-7686)
- Dhruv S Kazi
- Adam Hively (ORCID: https://orcid.org/0009-0003-0501-2887)
- Noelle Le Tourneau
Institutions
- San Francisco General Hospital (US)
- Harvard University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Washington University in St. Louis (US)
- VA Palo Alto Health Care System (US)
- University of California System (US)
- UNSW Sydney (AU)
- The George Institute for Global Health (AU)
- Global Solutions for Infectious Diseases (US)
- Deaconess Hospital (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of Cardiac Failure - Intersections
- Published
- 2025-11-20
- DOI
- https://doi.org/10.1016/j.yjcafi.2025.10.014
- Primary Topic
- Medication Adherence and Compliance
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Washington University in St. Louis
- Institute of Clinical and Translational Sciences
- National Institutes of Health
- University of California, San Francisco
- National Health and Medical Research Council
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases